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The addition of autologous stem cell transplantation to neoadjuvant chemotherapy, radiation, and HIPEC for patients with unresectable desmoplastic small round cell tumor: a single center case series

Authors:

Amir Siddiqui,

Department of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, University of Chicago, Chicago, IL, US
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MD

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Navin Pinto,

Department of Pediatrics, Division of Hematology/Oncology, University of Washington, Seattle, WA, US
About Navin

MD

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Mark A. Applebaum,

Department of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, University of Chicago, Chicago, IL, US
About Mark A.

MD

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Grace Z. Mak,

Department of Surgery, Section of Pediatric Surgery, University of Chicago, Chicago, IL, US
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MD

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John M. Cunningham,

Department of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, University of Chicago, Chicago, IL, US
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James L. LaBelle,

Department of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, University of Chicago, Chicago, IL, JP
About James L.

MD, PhD

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Michele L. Nassin

Department of Pediatrics, Section of Hematology/Oncology/Stem Cell Transplantation, University of Chicago, 5841 S Maryland Ave. MC4060, Chicago, IL 60637, US
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MD, MS

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Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive malignancy primarily affecting children and young adults. Although modest improvements have been gained by intensification of chemotherapy and radiation, survival of patients with DSRCT remains poor, particularly in those with unresectable or disseminated disease. We report 3 pediatric patients who were treated with a combination of therapy including chemotherapy, surgical debulking, hyperthermic intraperitoneal chemotherapy, whole abdominal irradiation, and autologous hematopoietic stem cell transplantation following busulfan and melphalan conditioning. We find that this approach is well tolerated and may offer improved survival in patients with DSRCT.

How to Cite: Siddiqui A, Pinto N, Applebaum MA, Mak GZ, Cunningham JM, LaBelle JL, et al.. The addition of autologous stem cell transplantation to neoadjuvant chemotherapy, radiation, and HIPEC for patients with unresectable desmoplastic small round cell tumor: a single center case series. International Journal of Surgery: Oncology. 2021;5(6):e95. DOI: http://doi.org/10.1097/IJ9.0000000000000095
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Published on 20 Jan 2021.
Peer Reviewed

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