Start Submission Become a Reviewer

Reading: Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma...

Download

A- A+
Alt. Display

Article

Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report

Authors:

Takashi Imajima,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Takashi

MD

X close

Mamoru Ito,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Mamoru

MD

X close

Yudai Shinohara,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Yudai

MD

X close

Kenji Tsuchihashi,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Kenji

MD, PhD

X close

Hiroshi Ariyama,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Hiroshi

MD, PhD

X close

Hitoshi Kusaba,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Hitoshi

MD, PhD

X close

Hidetaka Yamamoto,

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
About Hidetaka

MD, PhD

X close

Yoshinao Oda,

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
About Yoshinao

MD, PhD

X close

Koichi Akashi,

Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Koichi

MD, PhD

X close

Eishi Baba

Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JP
About Eishi

MD, PhD

X close

Abstract

Introduction: Most cases of cutaneous apocrine carcinoma (CAC) express androgen receptor. Androgen signal is thought to have a relationship on the survival and cell growth of the tumor.

Presentation of Case: A 53-year-old man with a red superficial nodule on the left axilla and a back pain was diagnosed with CAC in the left axilla with multiple bone and bone marrow metastases. After cytotoxic chemotherapy for around 4 years, severe anemia, thrombocytopenia, and disseminated intravascular coagulation progressed. We started combined androgen blockade by bicaltamide and degarelix, and the therapy had successfully maintained stable disease for more than 6 months.

Discussion: Most cases of CAC express androgen receptor. Androgen signal could have a relationship on the survival and cell growth of the tumor.

Conclusion: Antiandrogen therapy for androgen-receptor positive CAC is a promising therapeutic option.

How to Cite: Imajima T, Ito M, Shinohara Y, Tsuchihashi K, Ariyama H, Kusaba H, et al.. Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report. International Journal of Surgery: Oncology. 2021;5(6):e105. DOI: http://doi.org/10.1097/IJ9.0000000000000105
17
Views
4
Downloads
Published on 06 Jan 2021.
Peer Reviewed

Downloads

  • PDF (EN)