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    Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report

    Authors:

    Takashi Imajima,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Takashi

    MD

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    Mamoru Ito,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Mamoru

    MD

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    Yudai Shinohara,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Yudai

    MD

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    Kenji Tsuchihashi,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Kenji

    MD, PhD

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    Hiroshi Ariyama,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Hiroshi

    MD, PhD

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    Hitoshi Kusaba,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
    About Hitoshi

    MD, PhD

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    Hidetaka Yamamoto,

    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
    About Hidetaka

    MD, PhD

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    Yoshinao Oda,

    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
    About Yoshinao

    MD, PhD

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    Koichi Akashi,

    Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
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    MD, PhD

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    Eishi Baba

    Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JP
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    MD, PhD

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    Abstract

    Introduction: Most cases of cutaneous apocrine carcinoma (CAC) express androgen receptor. Androgen signal is thought to have a relationship on the survival and cell growth of the tumor.

    Presentation of Case: A 53-year-old man with a red superficial nodule on the left axilla and a back pain was diagnosed with CAC in the left axilla with multiple bone and bone marrow metastases. After cytotoxic chemotherapy for around 4 years, severe anemia, thrombocytopenia, and disseminated intravascular coagulation progressed. We started combined androgen blockade by bicaltamide and degarelix, and the therapy had successfully maintained stable disease for more than 6 months.

    Discussion: Most cases of CAC express androgen receptor. Androgen signal could have a relationship on the survival and cell growth of the tumor.

    Conclusion: Antiandrogen therapy for androgen-receptor positive CAC is a promising therapeutic option.

    Keywords: Apocrine carcinoma, Androgen receptor, Antiandrogen therapy, Combination androgen blockade, Case report
    How to Cite: Imajima T, Ito M, Shinohara Y, Tsuchihashi K, Ariyama H, Kusaba H, et al.. Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report. International Journal of Surgery: Oncology. 2021;5(6):e105. DOI: http://doi.org/10.1097/IJ9.0000000000000105
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    Published on 06 Jan 2021.
    Peer Reviewed
    CC BY 4.0

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