Article
Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report
Authors:
Takashi Imajima,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Takashi
MD
Mamoru Ito,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Mamoru
MD
Yudai Shinohara,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Yudai
MD
Kenji Tsuchihashi,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Kenji
MD, PhD
Hiroshi Ariyama,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Hiroshi
MD, PhD
Hitoshi Kusaba,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Hitoshi
MD, PhD
Hidetaka Yamamoto,
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
About Hidetaka
MD, PhD
Yoshinao Oda,
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JP
About Yoshinao
MD, PhD
Koichi Akashi,
Department of Hematology, Oncology and Cardiovascular Disease, Kyushu University Hospital, Fukuoka, JP
About Koichi
MD, PhD
Eishi Baba
Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JP
About Eishi
MD, PhD
Abstract
Introduction: Most cases of cutaneous apocrine carcinoma (CAC) express androgen receptor. Androgen signal is thought to have a relationship on the survival and cell growth of the tumor.
Presentation of Case: A 53-year-old man with a red superficial nodule on the left axilla and a back pain was diagnosed with CAC in the left axilla with multiple bone and bone marrow metastases. After cytotoxic chemotherapy for around 4 years, severe anemia, thrombocytopenia, and disseminated intravascular coagulation progressed. We started combined androgen blockade by bicaltamide and degarelix, and the therapy had successfully maintained stable disease for more than 6 months.
Discussion: Most cases of CAC express androgen receptor. Androgen signal could have a relationship on the survival and cell growth of the tumor.
Conclusion: Antiandrogen therapy for androgen-receptor positive CAC is a promising therapeutic option.
How to Cite:
Imajima T, Ito M, Shinohara Y, Tsuchihashi K, Ariyama H, Kusaba H, et al.. Favorable response to combined androgen blockade for metastatic cutaneous apocrine carcinoma: a case report. International Journal of Surgery: Oncology. 2021;5(6):e105. DOI: http://doi.org/10.1097/IJ9.0000000000000105
Published on
06 Jan 2021.
Peer Reviewed
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