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Gestational choriocarcinoma with residual lung tumor after completing treatment: a case report

Authors:

Sara Centonze,

Department of Precision Medicine, Division of Medical Oncology, School of Medicine, “Luigi Vanvitelli” University of Campania, Naples, IT
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Elisena Franzese ,

Department of Precision Medicine, Division of Medical Oncology, School of Medicine, “Luigi Vanvitelli” University of Campania, Naples; Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale,” IRCCS, Naples 80131, IT
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Anna Diana,

Department of Precision Medicine, Division of Medical Oncology, School of Medicine, “Luigi Vanvitelli” University of Campania, Naples, IT
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Sandro Pignata,

Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale,” IRCCS, IT
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Fortunato Ciardiello,

Department of Precision Medicine, Division of Medical Oncology, School of Medicine, “Luigi Vanvitelli” University of Campania, Naples, IT
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Michele Orditura

Department of Precision Medicine, Division of Medical Oncology, School of Medicine, “Luigi Vanvitelli” University of Campania, Naples, IT
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Abstract

Introduction: Choriocarcinoma (CCA) is a malignant pregnancy-related tumor that originates from cytotrophoblast and syncytiotrophoblast cells without villi. CCA is the most metastatic form among gestational trophoblastic neoplasia and the diagnosis is often in advanted stage.

Patient concerns: In this report, we present a rare case of CCA with lung metastasis after term pregnancy in a 41-year-old woman at 45 days after the birth of a healthy baby and discuss management of residual metastasis after completing treatment.

Diagnosis: The diagnosis of CCA can be based on the following criteria: a human chorionic gonadotropin (hCG) plateau for at least 4 values over 3 weeks, an hCG increase of 10% or greater for at least 3 values over 2 weeks, hCG persistence for 6 months or more after molar pregnancy evacuation, histopathologic diagnosis of choriocarcinoma and presence of metastatic disease.

Intervention and outcomes: High risk patients must be treated with multiagent chemotherapy (EMA-CO schedule). The complete remission rates ranges from 69% to 86%.

Conclusion: Residual lesions after chemotherapy are often the result of necrosis or fibrosis. In our clinical practice will avoid the risks deriving from excessive anticancer treatment in these patients, while favoring a strict follow-up strategy to monitor disease behavior in time.

How to Cite: Centonze S, Franzese E, Diana A, Pignata S, Ciardiello F, Orditura M. Gestational choriocarcinoma with residual lung tumor after completing treatment: a case report. International Journal of Surgery: Oncology. 2021;5(6):e107. DOI: http://doi.org/10.1097/IJ9.0000000000000107
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Published on 06 Jan 2021.
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